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Oshikoto is named after Lake Otjikoto near its former capital Tsumeb. The new capital of Oshikoto is Omuthiya.

Tsumeb Guesthouse Kamho is an exciting new resort and conference centre set in the heart of the charming, picturesque town of Tsumeb, the house of Annual Copper Cultural Festival. The guesthouse is a most rewarding stop-over for any trip to Etosha National Park, Oshana, Omusati, Ohangwena, Kavango and Zambezi Regions.

The northern part of the region is agricultural, whereas the main economic activities in the southern part are cattle rearing and mining.
The two areas have important cultural and historical links in that the Ndonga people have extracted copper at Tsumeb since the earliest times in order to make rings and tools.

Oshikoto is one of only three regions without either a shoreline or a foreign border.